We are uPATCH

“A healthy life should be easily accessible to every person on earth. We aim to make that happen by facilitating the introduction of microneedles to end-users as soon as possible.”

The Journey So Far

Here is our history. It’s not very full right now. We’ll contact some historians to help us out with this one. Stay tuned.

Are you passionate about the potential of microneedles too?

We would love to hear from you!


The natural progression of microneedle technologies requires collaboration between any and all practitioners. Together we can bring microneedles to the masses and make it an industry standard!


Don’t hesitate to contact us with any questions – if we can’t answer them ourselves, we might be able to connect you with somebody else we’ve been talking to.

    Associated Publications

    de Groot AM, Platteel ACM, Kuijt N, van Kooten PJS, Vos PJ, Sijts AJAM and van der Maaden K (2017) Nanoporous Microneedle Arrays Effectively Induce Antibody Responses against Diphtheria and Tetanus Toxoid. Front. Immunol. 8:1789. doi: 10.3389/fimmu.2017.01789
    K. van der Maaden et al., Hollow microneedle-mediated micro-injections of a liposomal HPV E743-63 synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses, 269 (2017), pages 347-354
    P. Schipper et al., Diphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pHsensitive microneedles induce potent immune responses upon dermal vaccination in mice, Journal of controlled release, 262 (2017), pages 28-36
    Maaden K. van der, Heuts J.M.M., Camps M.G.M., Pontier M.J., Terwisscha van Scheltinga A., Jiskoot W., Ossendorp F.A. & Bouwstra J.A. (2018), Hollow microneedle-mediated micro-injections of a liposomal HPV E7(43-63) synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses, JOURNAL OF CONTROLLED RELEASE 269: 347-354.
    Tu J., Du G., Reza Nejadnik M., Monkare J.T., Maaden K. van der, Bomans P.H.H., Sommerdijk N.A.J.M., Slutter B., Jiskoot W., Bouwstra J.A. & Kros A. (2017), Mesoporous Silica Nanoparticle-Coated Microneedle Arrays for Intradermal Antigen Delivery, Pharmaceutical Research 34(8): 1693-1706.
    Schipper P., Maaden K. van der, Romeijn S., Oomens C., Kersten G., Jiskoot W. & Bouwstra J. (2016), Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles., PHARMACEUTICAL RESEARCH 33(9): 2269-2279.
    Schipper P., Maaden K. van der, Romeijn S., Oomens C., Kersten G., Jiskoot W. & Bouwstra J. (2016), Repeated fractional intradermal dosing of an inactivated polio vaccine by a single hollow microneedle leads to superior immune responses., Journal of controlled release : official journal of the Controlled Release Society 242: 141-147.
    Maaden K. van der, Sekerdag E., Schipper P., Kersten G.F.A., Jiskoot W. & Bouwstra J.A. (2015), Layer-by-Layer Assembly of Inactivated Poliovirus and N-Trimethyl Chitosan on pH-Sensitive Microneedles for Dermal Vaccination., Langmuir : the ACS journal of surfaces and colloids 31(31): 8654-60.
    Varypataki E.M., Maaden K. van der, Bouwstra J.A., Ossendorp F.A. & Jiskoot W. (2015), Cationic Liposomes Loaded with a Synthetic Long Peptide and Poly(I:C): a Defined Adjuvanted Vaccine for Induction of Antigen-Specific T Cell Cytotoxicity, AAPS JOURNAL 17(1): 216-226.
    Maaden K. van der, Luttge R., Vos P.J., Bouwstra J., Kersten G. & Ploemen I. (2015), Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays, DRUG DELIVERY AND TRANSLATIONAL RESEARCH 5: 397-406.
    van der Maaden Koen, Varypataki Eleni Maria, Yu Huixin, Romeijn Stefan, Jiskoot Wim & Bouwstra Joke (2014), Parameter optimization toward optimal microneedle-based dermal vaccination, 64: 18-25.
    Maaden K. van der, Varypataki E.M., Romeijn S.G., Ossendorp F.A., Jiskoot W. & Bouwstra J.A. (2014), Ovalbumin-coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice, European Journal of Pharmaceutics and Biopharmaceutics 88(2): 310-315.
    van der Maaden Koen, Sekerdag Emine, Jiskoot Wim & Bouwstra Joke (2014), Impact-Insertion Applicator Improves Reliability of Skin Penetration by Solid Microneedle Arrays, AAPS JOURNAL 16(4): 681-684.
    Maaden K. van der, Trietsch S.J., Kraan H., Varypataki E.M., Romeijn S., Zwier R., Linden H.J. van der, Kersten G., Hankemeier T., Jiskoot W. & Bouwstra J. (2014), Novel Hollow Microneedle Technology for Depth-Controlled Microinjection-Mediated Dermal Vaccination: A Study with Polio Vaccine in Rats, PHARMACEUTICAL RESEARCH 31(7): 1846-1854.
    Maaden K. van der, Yu H., Sliedregt K., Zwier R., Leboux R., Oguri M., Kros A., Jiskoot W. & Bouwstra J.A. (2013), Nanolayered chemical modification of silicon surfaces with ionizable surface groups for pH-triggered protein adsorption and release: application to microneedles, Journal of Materials Chemistry. B 1(35): 4466-4477.
    Maaden K. van der, Jiskoot W. & Bouwstra J.A. (2012), Microneedle technologies for (trans)dermal drug and vaccine delivery, JOURNAL OF CONTROLLED RELEASE 161(2): 645-655.
    Maaden K. van der, Sliedregt K., Kros A., Jiskoot W. & Bouwstra J. (2012), Fluorescent Nanoparticle Adhesion Assay: a Novel Method for Surface pK(a) Determination of Self-Assembled Monolayers on Silicon Surfaces, LANGMUIR 28(7): 3403-3411.
    Carstens M.G., Maaden K. van der, Velden D. van der, Ottenhoff T.H., Melief C.J., Ossendorp F., Bouwstra J.A. & Jiskoot W. (2011), Evaluation of the high-pressure extrusion technique as a method for sizing plasmid DNA-containing cationic liposomes, Journal of Liposome Research 21(4): 286-295.