Associated Publications

In these scientific publications, we have demonstrated the best principles for applying microneedles to the skin.

Custom Applicator

Vaccination with influenza hemagglutinin-loaded ceramic nanoporous microneedle arrays induces protective immune responses, Eur J Pharm Biopharm 

B. Schepens, P. J. Vos, X. Saelens, K. van der Maaden, 136 (2019) 259-266

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Nanoporous microneedle arrays effectively induce antibody responses against diphtheria and tetanus toxoid, Frontiers Immunol

A. M. de Groot, A. Platteel, N. Kuijt, P. van Kooten, P. J. Vos, A. Sijts, K. van der Maaden, 8 (2017)

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APA-V0 - Adjustable Precision Applicator (uPATCH CHECK)

Hollow microneedle-mediated micro-injections of a liposomal HPV E743-63 synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses, J Control Release 

K. van der Maaden, J. Heuts, M. Camps, M. Pontier, A. Terwisscha van Scheltinga, W. Jiskoot, F. Ossendorp, J. Bouwstra, 269 (2018) 347-354

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Coated and hollow microneedle-mediated intradermal immunization in mice with diphtheria toxoid loaded mesoporous silica nanoparticles, Pharm Res 

G. Du, L. Woythe, K van der Maaden, M. Leone, S. G. Romeijn, A. Kros, G. F. A. Kersten, W. Jiskoot, J. A. Bouwstra, 35 (2018)

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Hyaluronan-based dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment

M. Leone, M. I. Priester, S. Romeijna, M. R. Nejadnik, J. Mönkäre, C. O'Mahony, W. Jiskoot, G. Kersten, J. A.Bouwstra, EJPB 134 (2019) 49-59

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Hyaluronan Molecular Weight: Effects on Dissolution Time of Dissolving Microneedles in the Skin and on Immunogenicity of Antigen, Eur J Pharm Sci 

M. Leone, S. Romeijn, B. Slütter, C. O'Mahony, G. Kersten, J. A Bouwstra, (2020)

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Diphtheria Toxoid Dissolving Microneedle Vaccination: Adjuvant Screening and Effect of Repeated-Fractional Dose Administration, Int J Pharm 

M. Leone, S. Romeijn, G. Du, S. E. Le Dévédec, H. Vrieling, C. O'Mahony, J. A. Bouwstra, G. Kersten, (2020)

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APA-V1 - Adjustable Precision Applicator (uPATCH CHECK)

Nanoporous microneedle arrays seamlessly connected to a drug reservoir for tunable transdermal delivery of memantine 

P. J. Vos, N. Kuijt, M. Kaya, S. Rol, K. van der Maaden, accepted for publication(2020) Eur J Pharm Sci

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Universal applicator for digitally-controlled pressing force and impact velocity insertion of microneedles into skin

M. Leone, B. H. van Oorschot, M. R. Nejadnik, A. Bocchino, M Rosato, G. Kersten, C. O’Mahony, J. Bouwstra, K. van der Maaden, Pharmaceutics 10 (2018)

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Microneedle associated publications

 Nanoporous microneedle arrays seamlessly connected to a drug reservoir for tunable transdermal delivery of memantine

P. J. Vos, N. Kuijt, M. Kaya, S. Rol, K. van der Maaden*, accepted for publication (2020) Eur J Pharm Sci

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Vaccination with influenza hemagglutinin-loaded ceramic nanoporous microneedle arrays induces protective immune responses

B. Schepens, P. J. Vos, X. Saelens, K. van der Maaden*, Eur J Pharm Biopharm 136 (2019) 259-266

See full publication
Universal applicator for digitally-controlled pressing force and impact velocity insertion of microneedles into skin

M. Leone, B. H. van Oorschot, M. R. Nejadnik, A. Bocchino, M Rosato, G. Kersten, C. O’Mahony, J. Bouwstra, K. van der Maaden*, Pharmaceutics 10 (2018)

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Hollow microneedle-mediated micro-injections of a liposomal HPV E743-63 synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses

K. van der Maaden, J. Heuts, M. Camps, M. Pontier, A. Terwisscha van Scheltinga, W. Jiskoot, F. Ossendorp, J. Bouwstra, J Control Release 269 (2018) 347-354

See full publication
Coated and hollow microneedle-mediated intradermal immunization in mice with diphtheria toxoid loaded mesoporous silica nanoparticles

G. Du, L. Woythe, K van der Maaden, M. Leone, S. G. Romeijn, A. Kros, G. F. A. Kersten, W. Jiskoot, J. A. Bouwstra, Pharm Res 35 (2018)

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Nanoporous microneedle arrays effectively induce antibody responses against diphtheria and tetanus toxoid

A. M. de Groot, A. Platteel, N. Kuijt, P. van Kooten, P. J. Vos, A. Sijts, K. van der Maaden*, Frontiers Immunol 8 (2017)

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Mesoporous silica nanoparticle-coated microneedle arrays for intradermal antigen delivery

J. Tu, G. Du, M. R. Nejadnik, J. Mönkäre, K. van der Maaden, P. H. H. Bomans, N. A. J. M. Sommerdijk, B. Slütter, W. Jiskoot, J. A. Bouwstra, A. Kros, Pharm Res 34 (2017) 1693-1706

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Diphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice

P. Schipper, K. van der Maaden, V. Groeneveld, M. Ruigrok, S.G. Romeijn, S. Uleman, C. Oomens, G. Kersten, W. Jiskoot, J. Bouwstra, J Control Release 262 (2017) 28-36

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Repeated fractional intradermal dosing of an inactivated polio vaccine by a single hollow microneedle leads to superior immune responses

P. Schipper, K. van der Maaden, S.G. Romeijn, C. Oomens, G. Kersten, W. Jiskoot, J. Bouwstra, J Control Release 242 (2016) 141-147

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Determination of depth-dependent intradermal immunogenicity of adjuvanted inactivated polio vaccine delivered by microinjections via hollow microneedles

P. Schipper, K. van der Maaden, S.G. Romeijn, C. Oomens, G. Kersten, W. Jiskoot, J. Bouwstra, Pharm Res, 33 (2016) 2269-2279

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Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays

K. van der Maaden, R. Luttge, P.J. Vos, J. Bouwstra, G. Kersten, I. Ploemen, Drug Deliv Transl Res 5 (2015) 397-406

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Layer-by-layer assembly of inactivated poliovirus and N-trimethyl chitosan on pH-sensitive microneedles for dermal vaccination

K. van der Maaden, E. Sekerdag, P. Schipper, G. Kersten, W. Jiskoot, J. Bouwstra, Langmuir, 31 (2015) 8654-8660.

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Ovalbumin-coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice

K. van der Maaden, E.M. Varypataki, S. Romeijn, F. Ossendorp, W. Jiskoot, J. Bouwstra, Eur J Pharm Biopharm, 88 (2014) 310-315.

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Parameter optimization toward an optimal efficiency of the ‘poke and patch’ microneedle application method for dermal vaccination

K. van der Maaden, E.M. Varypataki, H. Yu, S. Romeijn, W. Jiskoot, J. Bouwstra, Eur J Pharm Sci, 64 (2014) 18-25.

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Impact-insertion applicator improves reliability of skin penetration by solid microneedle arrays

K. van der Maaden, E. Sekerdag, W. Jiskoot, J. Bouwstra, AAPS J, 16 (2014) 681-684.

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Novel hollow microneedle technology for depth-controlled microinjection-mediated dermal vaccination: a study with polio vaccine in rats

K. van der Maaden, S. J. Trietsch, H. Kraan, E. M. Varypataki, S. Romeijn, R. Zwier, H.J. van der Linden, G. Kersten, T. Hankemeier, W. Jiskoot, J. Bouwstra, Pharm Res, 31 (2014) 1846–1854.

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Nanolayered chemical modification of silicon surfaces with ionizable surface groups for pH-triggered protein adsorption and release: application to microneedles

K. van der Maaden, H. Yu, K. Sliedregt, R. Zwier, R. Leboux, M. Oguri, A. Kros, W. Jiskoot, J. Bouwstra, J Mat Chem B, 1 (2013) 4466-4477.

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Microneedle technologies for (trans)dermal drug and vaccine delivery

K. van der Maaden, W. Jiskoot, J. Bouwstra, J Control Release, 161 (2012) 645-655.

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